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  3. ADRB1 Protein, Mouse (Cell-Free, His, SUMO)

ADRB1 Protein, Mouse (Cell-Free, His, SUMO)

Cat. No.: HY-P702205
Handling Instructions

The ADRB1 protein is a beta-adrenergic receptor that critically mediates catecholamine-induced adenylyl cyclase activation through G-protein action. It has the same affinity for epinephrine and norepinephrine and responds to endogenous catecholamines. ADRB1 Protein, Mouse (Cell-Free, His, SUMO) is the recombinant mouse-derived ADRB1 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of ADRB1 Protein, Mouse (Cell-Free, His, SUMO) is 466 a.a., with molecular weight of 63.4 kDa.

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Description

The ADRB1 protein is a beta-adrenergic receptor that critically mediates catecholamine-induced adenylyl cyclase activation through G-protein action. It has the same affinity for epinephrine and norepinephrine and responds to endogenous catecholamines. ADRB1 Protein, Mouse (Cell-Free, His, SUMO) is the recombinant mouse-derived ADRB1 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of ADRB1 Protein, Mouse (Cell-Free, His, SUMO) is 466 a.a., with molecular weight of 63.4 kDa.

Background

The ADRB1 Protein, a member of the beta-adrenergic receptor family, plays a crucial role in mediating catecholamine-induced activation of adenylate cyclase through G protein action. Notably, this receptor exhibits approximately equal affinity for both epinephrine and norepinephrine, highlighting its responsiveness to both endogenous catecholamines. ADRB1 is implicated in Ras activation through G(s)-alpha- and cAMP-mediated signaling. Additionally, its involvement in the regulation of sleep/wake behaviors underscores its broader physiological significance. The protein interacts directly with RAPGEF2 via its C-terminus PDZ motif and shows associations with GOPC, MAGI3, and DLG4, further contributing to the intricate regulation of ADRB1 signaling and its potential role in diverse cellular processes.

Species

Mouse

Source

E. coli Cell-free

Tag

N-6*His;N-SUMO

Accession

P34971 (M1-V466)

Gene ID

11554

Molecular Construction
N-term
6*His-SUMO
ADRB1 (M1-V466)
Accession # P34971
C-term
Synonyms
Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor
AA Sequence

MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDSSLDEPGRQGFSSESKV

Molecular Weight

63.4 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

ADRB1 Protein, Mouse (Cell-Free, His, SUMO) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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ADRB1 Protein, Mouse (Cell-Free, His, SUMO)
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HY-P702205
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