AMP Kinase β2 Protein, Human (His)

AMP kinase β2 protein is the non-catalytic subunit of AMP-activated protein kinase (AMPK), which regulates cellular energy metabolism. When a decrease in ATP levels is detected, AMPK activates energy-generating pathways and inhibits biosynthesis and cell growth. AMP Kinase β2 Protein, Human (His) is the recombinant human-derived AMP Kinase β2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of AMP Kinase β2 Protein, Human (His) is 271 a.a., .

AMP Kinase β2 protein functions as the non-catalytic subunit within the AMP-activated protein kinase (AMPK), a pivotal energy sensor kinase crucial for cellular energy metabolism regulation. Upon sensing a decrease in intracellular ATP levels, AMPK orchestrates a response that activates energy-generating pathways while concurrently inhibiting energy-consuming processes, including protein, carbohydrate, and lipid biosynthesis, as well as cell growth and proliferation. This regulatory role is achieved through direct phosphorylation of metabolic enzymes and, over a longer timeframe, via the phosphorylation of transcription regulators. Additionally, AMP Kinase β2 contributes to the maintenance of cellular polarity by modulating the actin cytoskeleton, potentially by indirectly activating myosin. Serving as a scaffold, the beta non-catalytic subunit facilitates the assembly of the AMPK complex, connecting the alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2, or PRKAG3) through its C-terminus. The AMPK complex operates as a heterotrimer, essential for orchestrating the intricate balance of cellular energy dynamics.

Human

E. coli

N-6*His

O43741 (G2-I272)

5565

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.