AQP5 Protein, Human (Cell-Free, His)

The AQP5 protein forms water-specific channels that are essential for fluid secretion in salivary glands. AQP5 Protein, Human (Cell-Free, His) is the recombinant human-derived AQP5 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of AQP5 Protein, Human (Cell-Free, His) is 265 a.a., with molecular weight of 31.1 kDa.

AQP5, functioning as a water-specific channel, plays a crucial role in fluid secretion within salivary glands and contributes to the activation of TRPV4 by hypotonicity. Alongside TRPV4, AQP5 is involved in regulating volume decrease in salivary epithelial cells. While essential for these processes, AQP5 appears to have a redundant role in water transport in other tissues such as the eye, lung, and sweat glands. Structurally, AQP5 forms homotetramers, and it interacts with TRPV4, albeit likely indirectly, to modulate TRPV4 activation in response to hypotonic conditions. This interaction underscores the cooperative involvement of AQP5 and TRPV4 in cellular responses to changes in osmotic conditions.

Human

E. coli Cell-free

N-10*His

P55064 (M1-R265)

362

MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR

31.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.