ASTL/SAS1B Protein, Mouse (His)

ASTL/SAS1B Protein, an oocyte-specific receptor, plays a pivotal role in sperm-egg adhesion, crucial for fertilization. It inhibits polyspermy, preventing multiple sperm from fertilizing one egg. ASTL/SAS1B likely acts as a post-fertilization protease, cleaving ZP2 in the zona pellucida. This cleavage, occurring after fertilization and cortical granule exocytosis, renders the zona pellucida unsupportive of additional sperm binding, regulating fertilization processes. ASTL/SAS1B Protein, Mouse (His) is the recombinant mouse-derived ASTL/SAS1B protein, expressed by E. coli, with N-His labeled tag. The total length of ASTL/SAS1B Protein, Mouse (His) is 412 a.a., with molecular weight of ~46.2 kDa.

ASTL/SAS1B Protein serves as an oocyte-specific oolemmal receptor crucial for sperm and egg adhesion, playing a pivotal role in the process of fertilization. This protein assumes significance in the inhibition of polyspermy, indicating its involvement in preventing multiple sperm from fertilizing a single egg. ASTL/SAS1B likely functions as a protease responsible for the post-fertilization cleavage of ZP2, a component of the zona pellucida. The cleavage of ZP2 occurs at the surface of the zona pellucida following fertilization and cortical granule exocytosis. This enzymatic activity renders the zona pellucida incapable of supporting further sperm binding, contributing to the regulation of fertilization processes.

Mouse

E. coli

N-His

Q6HA09 (A24-D435)

215095  [NCBI]

Approximately 46.2 kDa

Greater than 95% as determined by Tris-Bis PAGE

<1 EU/μg, determined by LAL method.