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  5. Basigin/CD147 Protein, Human (HEK293, His)

Basigin/CD147 Protein, Human (HEK293, His)

Cat. No.: HY-P70029
COA Handling Instructions

Basigin/BSG proteins are critical for retinal maturation and development and function as retinal cell receptors for NXNL1, promoting the survival of retinal cone photoreceptors. Basigin/CD147 Protein, Human (HEK293, His) is the recombinant human-derived Basigin/CD147 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Basigin/CD147 Protein, Human (HEK293, His) is 184 a.a., with molecular weight of 30-40 kDa.

For research use only. We do not sell to patients.

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Description

Basigin/BSG proteins are critical for retinal maturation and development and function as retinal cell receptors for NXNL1, promoting the survival of retinal cone photoreceptors. Basigin/CD147 Protein, Human (HEK293, His) is the recombinant human-derived Basigin/CD147 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Basigin/CD147 Protein, Human (HEK293, His) is 184 a.a., with molecular weight of 30-40 kDa.

Background

Basigin/BSG protein is essential for the normal maturation and development of the retina, functioning as a critical cell surface receptor for NXNL1 and playing a pivotal role in NXNL1-mediated survival of retinal cone photoreceptors. Collaborating with glucose transporter SLC16A1/GLUT1 and NXNL1, Basigin/BSG promotes the survival of retinal cones by facilitating aerobic glycolysis and accelerating glucose entry into photoreceptors. Additionally, it serves as a potent inducer of IL6 secretion in various cell lines, including monocytes. In the context of microbial infection, Basigin/BSG acts as an erythrocyte receptor for P. falciparum RH5, playing an indispensable role in erythrocyte invasion by the merozoite stage of P. falciparum isolates 3D7 and Dd2. These diverse functions highlight the multifaceted roles of Basigin/BSG in cellular processes and host-pathogen interactions.

Species

Human

Source

HEK293

Tag

C-6*His

Accession

P35613-2 (A22-H205)

Gene ID

682  [NCBI]

Synonyms
rHuBasigin/CD147, His ; Basigin; 5F7; Collagenase Stimulatory Factor; Extracellular Matrix Metalloproteinase Inducer; EMMPRIN; Leukocyte Activation Antigen M6; OK Blood Group Antigen; Tumor Cell-Derived Collagenase Stimulatory Factor; TCSF; CD147; BSG
AA Sequence

AAGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSH

Molecular Weight

30-40 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Basigin/CD147 Protein, Human (HEK293, His)
Cat. No.:
HY-P70029
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