C5AR2 Protein, Human (Cell-Free, His)

The C5AR2 protein is a receptor for C3a, C4a, and C5a peptides as well as ASP/C3adesArg, C4adesArg, and C5adesArg, and is weakly coupled to G(i)-mediated signaling pathways. It interacts with C3 and exhibits higher affinity for the lipogenic hormone ASP. C5AR2 Protein, Human (Cell-Free, His) is the recombinant human-derived C5AR2 protein, expressed by E. coli Cell-free , with C-10*His labeled tag. The total length of C5AR2 Protein, Human (Cell-Free, His) is 337 a.a., with molecular weight of 38.9 kDa.

The C5AR2 Protein acts as a receptor for the chemotactic and inflammatory C3a, C4a, and C5a anaphylatoxin peptides, as well as their dearginated forms ASP/C3adesArg, C4adesArg, and C5adesArg, respectively. While it couples weakly to G(i)-mediated signaling pathways, C5AR2 interacts with C3, specifically with higher affinity for ASP, the adipogenic hormone. This interaction enhances the phosphorylation and activation of GPR77, leading to the recruitment of ARRB2 to the cell surface and subsequent endocytosis of GRP77. This intricate signaling mechanism highlights the involvement of C5AR2 in mediating responses to anaphylatoxin peptides and ASP, suggesting its role in modulating immune and inflammatory processes.

Human

E. coli Cell-free

C-10*His

Q9P296 (M1-V337)

27202

MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

38.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.