CACNA1C Protein, Pig (Cell-Free, His)

The CACNA1C protein is the alpha-1C subunit of voltage-gated calcium channels that generate L-type calcium currents that are critical for calcium influx and sarcoplasmic release. Its role in excitation-contraction coupling is critical for cardiac development, rhythm regulation, and smooth muscle cell contraction. CACNA1C Protein, Pig (Cell-Free, His) is the recombinant pig-derived CACNA1C protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CACNA1C Protein, Pig (Cell-Free, His) is 169 a.a., with molecular weight of 22.3 kDa.

CACNA1C, the pore-forming alpha-1C subunit of the voltage-gated calcium channel, gives rise to L-type calcium currents, mediating the influx of calcium ions into the cytoplasm and triggering calcium release from the sarcoplasm. With a crucial role in excitation-contraction coupling in the heart, CACNA1C is essential for normal heart development, heart rhythm regulation, and the contraction of smooth muscle cells in blood vessels and the intestine. It plays a pivotal role in the regulation of blood pressure by contributing to the contraction of arterial smooth muscle cells. As a member of the 'high-voltage activated' (HVA) group, CACNA1C's long-lasting calcium channels are inhibited by dihydropyridines like isradipine and nifedipine. The channel activity is intricately regulated by Ca(2+) and calmodulin, with binding of STAC1, STAC2, or STAC3 inhibiting channel inactivation by Ca(2+) and calmodulin. Moreover, shear stress and pressure increase calcium channel activity, adding another layer of regulation to its dynamic functionality.

Pig

E. coli Cell-free

N-10*His

O35505 (F1-Y169)

100135490

FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY

22.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.