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  4. CACNG1 Protein, Mouse (Cell-Free, His)

CACNG1 Protein, Mouse (Cell-Free, His)

Cat. No.: HY-P702229
Handling Instructions

CACNG1 Protein, a regulatory subunit of the voltage-gated calcium channel, contributes to L-type calcium currents in skeletal muscle and modulates channel inactivation kinetics. Collaborating with CACNA1S, CACNB1 or CACNB2, and CACNA2D1, CACNG1 orchestrates a balanced 1:1:1:1 ratio channel assembly, influencing the voltage-gated calcium channel's functionality in skeletal muscle. CACNG1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CACNG1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CACNG1 Protein, Mouse (Cell-Free, His) is 223 a.a., with molecular weight of 26.6 kDa.

For research use only. We do not sell to patients.

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Description

CACNG1 Protein, a regulatory subunit of the voltage-gated calcium channel, contributes to L-type calcium currents in skeletal muscle and modulates channel inactivation kinetics. Collaborating with CACNA1S, CACNB1 or CACNB2, and CACNA2D1, CACNG1 orchestrates a balanced 1:1:1:1 ratio channel assembly, influencing the voltage-gated calcium channel's functionality in skeletal muscle. CACNG1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CACNG1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CACNG1 Protein, Mouse (Cell-Free, His) is 223 a.a., with molecular weight of 26.6 kDa.
Background

CACNG1 protein serves as a regulatory subunit of the voltage-gated calcium channel, contributing to the generation of L-type calcium currents in skeletal muscle. Its pivotal role extends to the modulation of channel inactivation kinetics. Within the calcium channel complex, CACNG1 collaborates with the pore-forming alpha subunit (CACNA1S) and other ancillary subunits, namely CACNB1 or CACNB2, and CACNA2D1. This intricate channel assembly consists of alpha, beta, gamma, and delta subunits in a balanced 1:1:1:1 ratio, wherein CACNB1 or CACNB2 are included. The orchestrated interaction of these components highlights CACNG1's involvement in shaping the functionality and characteristics of the voltage-gated calcium channel in skeletal muscle.
Species

Mouse
Source

E. coli Cell-free
Tag

N-10*His
Accession

O70578 (M1-H223)
Gene ID

12299
Molecular Construction
N-term
10*His
CACNG1 (M1-H223)
Accession # O70578
C-term
Synonyms
Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
AA Sequence

MSQTKTAKVRVTLFFILVGGVLAMVAVVTDHWAVLSPHLEHHNETCEAAHFGLWRICTARVAVHNKDKSCEHVTPSGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIIVGSICAFLSFGNKRDYLLRPASMFYAFAGLCLIVSVEVMRQSVKRMIDSEDTVWIEHYYSWSFACACAAFILLFLGGLFLLLFSLPRMPQNPWESCMDAEPEH

Molecular Weight

26.6 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CACNG1 Protein, Mouse (Cell-Free, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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