CD80 Protein, Human (Cell-Free, His)

The CD80 protein plays a key role in T lymphocyte activation, promoting proliferation and cytokine production through CD28 binding. In contrast, interaction with CTLA-4 inhibits T cell activation. CD80 Protein, Human (Cell-Free, His) is the recombinant human-derived CD80 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CD80 Protein, Human (Cell-Free, His) is 254 a.a., with molecular weight of 32.8 kDa.

The CD80 Protein plays a pivotal role in the costimulatory signal essential for T-lymphocyte activation, facilitating T-cell proliferation and cytokine production upon binding to CD28. Conversely, when interacting with CTLA-4, CD80 elicits opposite effects, inhibiting T-cell activation. In the context of microbial infection, CD80 also acts as a receptor for adenovirus subgroup B, further exemplifying its multifaceted involvement in immune responses and its recognition of diverse signaling cues. The intricate modulation of T-cell activation by CD80 underscores its significance in orchestrating adaptive immune responses and highlights its versatile functions in different physiological contexts.

Human

E. coli Cell-free

N-10*His

P33681 (V35-V288)

941

VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV

32.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.