CHMP4B Protein, Human

CHMP4B protein may be a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) and sorting of endosomal cargo proteins. It is essential for the degradation of membrane proteins delivered to lysosomes. CHMP4B Protein, Human is the recombinant human-derived CHMP4B protein, expressed by E. coli , with tag free. The total length of CHMP4B Protein, Human is 224 a.a., .

The CHMP4B protein stands out as a probable core component of the endosomal sorting required for transport complex III (ESCRT-III), playing a pivotal role in the formation of multivesicular bodies (MVBs) and the sorting of endosomal cargo proteins into these structures. MVBs, containing intraluminal vesicles (ILVs), are crucial for the degradation of membrane proteins like growth factor receptors, lysosomal enzymes, and lipids as they are delivered to lysosomes. The ESCRT-III complex, of which CHMP4B is a part, dissociates from the invaginating membrane before the ILV is released. Beyond its involvement in endosomal sorting, CHMP4B, in conjunction with SPAST, contributes to nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Additionally, CHMP4B plays a role in membrane fission events such as the budding of enveloped viruses, including HIV-1, interacting with PDCD6IP during HIV-1 p6- and p9-dependent virus release. The intricate functions of CHMP4B underscore its versatility in mediating crucial cellular processes.

Human

E. coli

Tag Free

Q9H444 (M1-M224)

128866

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.