DMPK Protein, Human (Sf9)

DMPK is a non-receptor serine/threonine protein kinase that is critical for skeletal muscle integrity, affecting myocyte differentiation, nuclear membrane integrity, and muscle-specific gene expression. It may inhibit myosin phosphatase (PPP1R12A), regulate myosin phosphorylation and affect cardiac contractility and conduction. DMPK Protein, Human (Sf9) is the recombinant human-derived DMPK protein, expressed by Sf9 insect cells , with tag free. The total length of DMPK Protein, Human (Sf9) is 629 a.a., .

DMPK, a non-receptor serine/threonine protein kinase, is essential for maintaining the structural and functional integrity of skeletal muscle. It likely contributes to myocyte differentiation and survival by influencing the nuclear envelope's integrity and the expression of muscle-specific genes. Additionally, DMPK may phosphorylate PPP1R12A, inhibiting myosin phosphatase activity and thereby regulating myosin phosphorylation. This kinase is crucial for modulating cardiac contractility and ensuring proper cardiac conduction activity, potentially through the regulation of cellular calcium homeostasis. DMPK's involvement extends to phosphorylating PLN, a regulator of calcium pumps, suggesting a role in modulating sarcoplasmic reticulum calcium uptake in myocytes. Furthermore, DMPK may phosphorylate FXYD1/PLM, known for inducing chloride currents, and might also play a role in synaptic plasticity.

Human

Sf9 insect cells

Tag Free

Q09013 (M1-P629)

1760

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.