DYRK1B Protein, Human (Sf9, GST)

DYRK1B protein has dual serine/threonine and tyrosine kinase activities. DYRK1B Protein, Human (Sf9, GST) is the recombinant human-derived DYRK1B protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of DYRK1B Protein, Human (Sf9, GST) is 628 a.a., .

DYRK1B, a dual-specificity kinase endowed with both serine/threonine and tyrosine kinase activities, assumes a critical role in cellular processes, particularly in ribosomal DNA (rDNA) double-strand break repair and the maintenance of rDNA copy number. During instances of DNA damage, DYRK1B orchestrates transcription silencing by phosphorylating and promoting the accumulation of double-strand breaks through the histone methyltransferase EHMT2. Beyond its involvement in DNA repair, DYRK1B exhibits versatile functions, enhancing the transcriptional activity of TCF1/HNF1A and FOXO1, inhibiting epithelial cell migration, and promoting survival of colon carcinoma cells in mitogen-poor environments. Moreover, DYRK1B modulates signaling pathways such as SHH and WNT1, thereby facilitating adipogenesis, and concurrently stimulates the expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). This multifaceted kinase emerges as a key regulator in diverse cellular processes, contributing to both DNA repair mechanisms and the modulation of crucial signaling pathways.

Human

Sf9 insect cells

N-GST

Q9Y463 (A2-S629)

9149

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.