EEF2K Protein, Human

EEF2K, a threonine kinase, critically regulates protein synthesis by modulating peptide chain elongation. Activation by upstream kinases like AMPK or TRPM7 leads to phosphorylation of EEF2, inhibiting its binding to ribosomes and decelerating protein synthesis. EEF2K's intricate control underscores its pivotal role in modulating cellular processes related to protein translation. EEF2K Protein, Human is the recombinant human-derived EEF2K protein, expressed by E. coli , with tag free. The total length of EEF2K Protein, Human is 724 a.a., .

EEF2K is a threonine kinase critically involved in the regulation of protein synthesis, acting as a key modulator of peptide chain elongation. Activation of EEF2K, triggered by various upstream kinases such as AMPK or TRPM7, leads to the phosphorylation of the elongation factor EEF2 at a specific site. This phosphorylation event renders EEF2 inactive, preventing its binding to ribosomes and, consequently, decelerating the rate of protein synthesis. The intricate control exerted by EEF2K in this molecular cascade highlights its pivotal role in modulating cellular processes related to protein translation.

Human

E. coli

Tag Free

O00418 (A2-E725)

29904

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.