FAAH2 Protein, Human (Cell-Free, His)

FAAH2 proteins play a central role in cellular processes by catalyzing the hydrolysis of endogenous amidated lipids, including the sleep-inducing lipid oleamide ((9Z)-octadecylamide) and the endocannabinoid anandamide (N-(5Z) , 8Z, 11Z, 14Z-eicosate tetraenoyl)))-ethanolamine) and other fatty amides. FAAH2 Protein, Human (Cell-Free, His) is the recombinant human-derived FAAH2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of FAAH2 Protein, Human (Cell-Free, His) is 532 a.a., with molecular weight of 59.8 kDa.

Fatty Acid Amide Hydrolase 2 (FAAH2) is an enzyme that catalyzes the hydrolysis of endogenous amidated lipids, including the sleep-inducing lipid oleamide ((9Z)-octadecenamide) and the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine). FAAH2 plays a crucial role in regulating the signaling functions of these bioactive molecules by converting them into their corresponding fatty acids. The enzyme exhibits a preference for monounsaturated substrates like anandamide over polyunsaturated ones. This hydrolytic activity on amidated lipids suggests FAAH2's involvement in the control and modulation of various physiological processes, including those related to sleep regulation and endocannabinoid signaling. It has to succinctly describe FAAH2's substrate specificity and its role in regulating the signaling functions of endogenous amidated lipids.

Human

E. coli Cell-free

N-10*His

Q6GMR7 (M1-F532)

158584

MAPSFTARIQLFLLRALGFLIGLVGRAALVLGGPKFASKTPRPVTEPLLLLSGMQLAKLIRQRKVKCIDVVQAYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQEDEATLENKWPFLGVPLTVKEAFQLQGMPNSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELCMWYESSNKIYGRSNNPYDLQHIVGGSSGGEGCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKPSPGVVPNKGQFPLAVGAQELFLCTGPMCRYAEDLAPMLKVMAGPGIKRLKLDTKVHLKDLKFYWMEHDGGSFLMSKVDQDLIMTQKKVVVHLETILGASVQHVKLKKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDHGKHVSPLWELIKWCLGLSVYTIPSIGLALLEEKLRYSNEKYQKFKAVEESLRKELVDMLGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFSALGLPVTQCPLGLNAKGLPLGIQVVAGPFNDHLTLAVAQYLEKTFGGWVCPGKF

59.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.