FRK Protein, Human (Sf9, GST)

FRK protein is a non-receptor tyrosine protein kinase that acts as a negative regulator of cell proliferation by positively regulating PTEN protein stability. Through phosphorylation of PTEN on “Tyr-336”, FRK may prevent PTEN ubiquitination and degradation by reducing its binding to NEDD4. FRK Protein, Human (Sf9, GST) is the recombinant human-derived FRK protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of FRK Protein, Human (Sf9, GST) is 504 a.a., .

FRK Protein, a non-receptor tyrosine-protein kinase, exerts its role as a negative regulator of cell proliferation. Its pivotal function involves the positive regulation of PTEN protein stability achieved through the phosphorylation of PTEN on 'Tyr-336'. This phosphorylation event prevents PTEN ubiquitination and degradation, potentially by reducing its binding to NEDD4. FRK Protein's ability to enhance PTEN stability suggests a regulatory mechanism that counteracts excessive cell proliferation, implying a potential tumor suppressor role for FRK Protein in cellular processes.

Human

Sf9 insect cells

N-GST

P42685 (S2-R505)

2444

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.