glycoprotein E/gE Protein, HHV-3 (Cell-Free, His, SUMO)

Glycoprotein E (gE) is an important component of the viral envelope and binds to the host cell entry receptor IDE. gE/gI heterodimers are critical in epithelial cells and facilitate cell-to-cell viral spread by sorting nascent viral particles to cell junctions. glycoprotein E/gE Protein, HHV-3 (Cell-Free, His, SUMO) is the recombinant Virus-derived glycoprotein E/gE protein, expressed by E. coli Cell-free , with N-10*His, N-SUMO labeled tag. The total length of glycoprotein E/gE Protein, HHV-3 (Cell-Free, His, SUMO) is 593 a.a., with molecular weight of 85.4 kDa.

Glycoprotein E (gE), an integral part of the envelope in viral structure, functions by binding to the potential host cell entry receptor IDE. Particularly crucial in epithelial cells, the heterodimer gE/gI plays a key role in facilitating the cell-to-cell spread of the virus. This is achieved by sorting nascent virions to cell junctions, where the virus can rapidly disseminate to adjacent cells through interactions with cellular receptors that accumulate at these junctions. In polarized cells, gE/gI is implicated in basolateral spread. In neuronal cells, this glycoprotein heterodimer is essential for the anterograde spread of the infection throughout the host nervous system. Collaborating with US9, gE/gI is also involved in the sorting and transport of viral structural components toward axon tips, contributing to the overall efficiency of the viral life cycle.

Virus

E. coli Cell-free

N-10*His;N-SUMO

P09259 (S31-R623)

1487709

SVLRYDDFHTDEDKLDTNSVYEPYYHSDHAESSWVNRGESSRKAYDHNSPYIWPRNDYDGFLENAHEHHGVYNQGRGIDSGERLMQPTQMSAQEDLGDDTGIHVIPTLNGDDRHKIVNVDQRQYGDVFKGDLNPKPQGQRLIEVSVEENHPFTLRAPIQRIYGVRYTETWSFLPSLTCTGDAAPAIQHICLKHTTCFQDVVVDVDCAENTKEDQLAEISYRFQGKKEADQPWIVVNTSTLFDELELDPPEIEPGVLKVLRTEKQYLGVYIWNMRGSDGTSTYATFLVTWKGDEKTRNPTPAVTPQPRGAEFHMWNYHSHVFSVGDTFSLAMHLQYKIHEAPFDLLLEWLYVPIDPTCQPMRLYSTCLYHPNAPQCLSHMNSGCTFTSPHLAQRVASTVYQNCEHADNYTAYCLGISHMEPSFGLILHDGGTTLKFVDTPESLSGLYVFVVYFNGHVEAVAYTVVSTVDHFVNAIEERGFPPTAGQPPATTKPKEITPVNPGTSPLLRYAAWTGGLAAVVLLCLVIFLICTAKRMRVKAYRVDKSPYNQSMYYAGLPVDDFEDSESTDTEEEFGNAIGGSHGGSSYTVYIDKTR

85.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.