glycoprotein E/gE Protein, HHV-3 (Cell-Free, His)

Glycoprotein E/gE proteins bind to the host cell entry receptor IDE. glycoprotein E/gE Protein, HHV-3 (Cell-Free, His) is the recombinant Virus-derived glycoprotein E/gE protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of glycoprotein E/gE Protein, HHV-3 (Cell-Free, His) is 593 a.a., with molecular weight of 68.4 kDa.

Envelope glycoprotein E (gE) functions as a key player in the viral life cycle by binding to the potential host cell entry receptor IDE. Particularly crucial in epithelial cells, the gE/gI heterodimer is essential for the efficient cell-to-cell spread of the virus, facilitating the sorting of nascent virions to cell junctions. Once positioned at these junctions, rapid virus dissemination to adjacent cells occurs through interactions with cellular receptors that accumulate at these sites. Additionally, gE/gI is implicated in basolateral spread in polarized cells. In neuronal cells, the gE/gI heterodimer plays a vital role in the anterograde spread of the infection throughout the host nervous system. Teaming up with US9, this heterodimer is involved in the sorting and transport of viral structural components toward axon tips, contributing to the orchestrated progression of the infection.

Virus

E. coli Cell-free

N-10*His

Q9J3M8 (S31-R623)

/

SVLRYDDFHIDEDKLDTNSVYEPYYHSDHAESSWVNRGESSRKAYDHNSPYIWPRNDYDGFLENAHEHHGVYNQGRGIDSGERLMQPTQMSAQEDLGDDTGIHVIPTLNGDDRHKIVNVDQRQYGDVFKGDLNPKPQGQRLIEVSVEENHPFTLRAPIQRIYGVRYTETWSFLPSLTCTGDAAPAIQHICLKHTTCFQDVVVDVDCAENTKEDQLAEISYRFQGKKEADQPWIVVNTSTLFDELELDPPEIEPGVLKVLRTEKQYLGVYIWNMRGSDGTSTYATFLVTWKGDEKTRNPTPAVTPQPRGAEFHMWNYHSHVFSVGDTFSLAMHLQYKIHEAPFDLLLEWLYVPIDPTCQPMRLYSTCLYHPNAPQCLSHMNSGCTFTSPHLAQRVASTVYQNCEHADNYTAYCLGISHMEPSFGLILHDGGTTLKFVDTPESLSGLYVFVVYFNGHVEAVAYTVVSTVDHFVNAIEERGFPPTAGQPPATTKPKEITPVNPGTSPLLRYAAWTGGLAAVVLLCLVIFLICTAKRMRVKAYRVDKSPYNQSMYYAGLPVDDFEDSESTDTEEEFGNAIGGSHGGSSYTVYIDKTR

68.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.