GPR62 Protein, Human (Cell-Free, His)

The GPR62 protein is an orphan G protein-coupled receptor that continuously activates the G(q/11)/phosphoinositide and G(s)-α/cAMP pathways. It exhibits spontaneous β-arrestin recruitment and may reciprocally regulate signaling through heteromerization, especially with MTNR1B. GPR62 Protein, Human (Cell-Free, His) is the recombinant human-derived GPR62 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of GPR62 Protein, Human (Cell-Free, His) is 368 a.a., with molecular weight of 39.1 kDa.

GPR62 Protein, an orphan G-protein coupled receptor, exhibits constitutive activation of the G(q/11)/inositol phosphate and G(s)-alpha/cAMP signaling pathways. Notably, it demonstrates spontaneous activity for beta-arrestin recruitment and engages in a reciprocal modulation of signaling functions, likely attributed to receptor heteromerization, particularly with the melatonin receptor MTNR1B. GPR62 forms homodimers and heterodimerizes with MTNR1B. The protein also interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner, leading to the internalization of GPR62 into the endosomal compartment. These dynamic interactions underscore the multifaceted regulatory roles of GPR62 in cellular signaling pathways.

Human

E. coli Cell-free

N-10*His

Q9BZJ7 (M1-S368)

118442

MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS

39.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.