Hemagglutinin neuraminidase/HN Protein, HPIV-3 (Cell-Free, His)

The hemagglutinin-neuraminidase (HN) protein is critical in viral infection, attaching the virus to sialic acid-containing cellular receptors to initiate infection. Binding induces conformational changes that enable the F protein to trigger virion-cell membrane fusion, thereby facilitating viral entry. Hemagglutinin neuraminidase/HN Protein, HPIV-3 (Cell-Free, His) is the recombinant Virus-derived Hemagglutinin neuraminidase/HN protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Hemagglutinin neuraminidase/HN Protein, HPIV-3 (Cell-Free, His) is 572 a.a., with molecular weight of 65.7 kDa.

The Hemagglutinin neuraminidase (HN) protein plays a crucial role in viral infection. It attaches the virus to cell receptors containing sialic acid, initiating the infection process. When the HN protein binds to the receptor, it induces a conformational change that enables the F protein to trigger fusion between the virion and cell membranes. This fusion event facilitates the entry of the virus into the host cell. Additionally, the HN protein exhibits neuraminidase activity, which aids in the efficient spread of the virus. By dissociating mature virions from neuraminic acid-containing glycoproteins, the HN protein enables the virus to propagate effectively.

Virus

E. coli Cell-free

N-10*His

P08492 (M1-S572)

/

MEYWKHTNHGKDAGNELETSMATHGNKITNKITYILWTIILVLLSIVFIIVLINSIKSEKAHESLLQDVNNEFMEVTEKIQMASDNINDLIQSGVNTRLLTIQSHVQNYIPISLTQQMSDLRKFISEITIRNDNQEVPPQRITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTVDGCVRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLNPRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIVNHDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLEHPINENAICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKGLNSIPKLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDYSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVSSVILDSQKSRVNPVITYSTSTERVNELAIRNKTLSAGYTTTSCITHYNKGYCFHIVEINHKSLDTFQPMLFKTEIPKSCS

65.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.