Hemagglutinin neuraminidase/HN Protein, Mumps virus strain SBL-1 (Cell-Free, His)

The hemagglutinin-neuraminidase (HN) protein is key to viral infection, attaching the virus to sialic acid-containing cell receptors and initiating infection. Its binding prompts structural changes that enable the F protein to initiate virion-cell membrane fusion, thereby facilitating viral entry. Hemagglutinin neuraminidase/HN Protein, Mumps virus strain SBL-1 (Cell-Free, His) is the recombinant Virus-derived Hemagglutinin neuraminidase/HN protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Hemagglutinin neuraminidase/HN Protein, Mumps virus strain SBL-1 (Cell-Free, His) is 582 a.a., with molecular weight of 65.4 kDa.

The Hemagglutinin neuraminidase (HN) protein is a key player in viral infection. It facilitates the attachment of the virus to cell receptors that contain sialic acid, initiating the infection process. When the HN protein binds to the receptor, it prompts a structural change that enables the F protein to initiate fusion between the virus and the cell membranes, facilitating the entry of the virus into the host cell. Additionally, the HN protein possesses neuraminidase activity, which plays a crucial role in the efficient spread of the virus. This activity helps in dissociating mature virions from glycoproteins containing neuraminic acid, allowing the virus to propagate effectively.

Virus

E. coli Cell-free

N-10*His

P19762 (M1-T582)

/

MEPSKLFIMSDNATVAPGPVVNAAGKKTFRTCFRILVLSVQAVTLILVIVTLGELIRMINDQGLSNQLSSITDKIRESAAVIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTNRNQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGNPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLEANDYAGSSPPTQKLTLLFYNDTITERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPPQELDQRALRSYFPRYFSSRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTPPGSGNCSGKNVCPTVCVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGTQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLARLTIT

65.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.