HIPK4 Protein, Human (Sf9, GST)

HIPK4 protein is a dynamic kinase that can phosphorylate human TP53 at the Ser-9 site, thereby initiating TP53 to inhibit the BIRC5 promoter. This critical role suggests its involvement in TP53-mediated cellular responses. HIPK4 Protein, Human (Sf9, GST) is the recombinant human-derived HIPK4 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of HIPK4 Protein, Human (Sf9, GST) is 615 a.a., .

HIPK4 protein, a dynamic kinase, plays a crucial role in cellular regulation by phosphorylating human TP53 at Ser-9, thereby instigating the repression of the BIRC5 promoter by TP53. This suggests a pivotal involvement in the intricate network of TP53-mediated cellular responses. Additionally, HIPK4 exhibits the potential to function as a corepressor of transcription factors, suggesting a broader influence on gene expression and transcriptional regulation. The dual roles of HIPK4 in TP53 phosphorylation and potential transcriptional corepression underscore its significance in modulating key cellular processes and contributing to the regulatory landscape of gene expression.

Human

Sf9 insect cells

N-GST

Q8NE63 (S2-H616)

147746

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.