HTR3D Protein, Human (Cell-Free, His, SUMO)

HTR3D protein functions as a subunit within serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes. Upon activation, these complexes induce rapid and depolarizing responses in neurons. This underscores the crucial role of HTR3D in mediating cellular responses to serotonin, contributing to the intricate network of signaling pathways involved in neurotransmission and neuronal excitability. HTR3D Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived HTR3D protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of HTR3D Protein, Human (Cell-Free, His, SUMO) is 234 a.a., with molecular weight of 41.5 kDa.

The HTR3D protein is a key component in the formation of serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes. Upon activation, these complexes induce fast, depolarizing responses in neurons. This highlights the critical role of HTR3D in mediating the cellular response to serotonin signaling. As a part of these channel complexes, HTR3D contributes to the regulation of neuronal excitability, impacting various physiological processes influenced by serotonin, such as mood, appetite, and cognition.

Human

E. coli Cell-free

N-6*His;N-SUMO

Q70Z44 (V221-T454)

200909

VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT

41.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.