IL13RA1 Protein, Human (Cell-Free, His)

The IL13RA1 protein is critical in immune signaling and binds with low affinity to IL13. It binds to IL4RA to form a functional IL13 receptor for cellular responses. IL13RA1 Protein, Human (Cell-Free, His) is the recombinant human-derived IL13RA1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of IL13RA1 Protein, Human (Cell-Free, His) is 406 a.a., with molecular weight of 52.6 kDa.

The IL13RA1 protein plays a vital role in immune signaling, exhibiting low-affinity binding to interleukin-13 (IL13). When partnered with IL4RA, it forms a functional receptor for IL13, facilitating the cellular response to this cytokine. Additionally, IL13RA1 serves as an alternate accessory protein alongside IL4RA for interleukin-4 (IL4) signaling, although it cannot replace the function of IL2RG in enhancing interleukin-2 (IL2) binding activity. The interleukin-13 receptor is a complex assembly comprising IL4R, IL13RA1, and possibly other components, indicating the intricate architecture of this signaling system. Moreover, IL13RA1 interacts with TRAF3IP1, suggesting its involvement in diverse cellular processes. Furthermore, IL13RA1 engages in interactions with IL4, underlining its multifaceted role in mediating responses to interleukin signaling pathways.

Human

E. coli Cell-free

N-10*His

P78552 (G22-Q427)

3597

GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ

52.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.