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  2. Enzymes & Regulators
  3. Protease Inhibitors
  4. Inter-Alpha-Trypsin Inhibitors (ITI)
  5. ITIH5
  6. ITIH5 Protein, Human (HEK293, His-hFc)

ITIH5 Protein, Human (HEK293, His-hFc)

Cat. No.: HY-P701322
COA Handling Instructions

The ITIH5 protein was identified as a potential tumor suppressor, indicating its critical role in controlling tumorigenesis. As a tumor suppressor, ITIH5 is expected to counteract uncontrolled cell growth and inhibit or regulate key pathways in tumor development. ITIH5 Protein, Human (HEK293, His-hFc) is the recombinant human-derived ITIH5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ITIH5 Protein, Human (HEK293, His-hFc) is 127 a.a., with molecular weight of ~50 kDa.

For research use only. We do not sell to patients.

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50 μg $400 In-stock
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Description

The ITIH5 protein was identified as a potential tumor suppressor, indicating its critical role in controlling tumorigenesis. As a tumor suppressor, ITIH5 is expected to counteract uncontrolled cell growth and inhibit or regulate key pathways in tumor development. ITIH5 Protein, Human (HEK293, His-hFc) is the recombinant human-derived ITIH5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ITIH5 Protein, Human (HEK293, His-hFc) is 127 a.a., with molecular weight of ~50 kDa.

Background

ITIH5 Protein emerges as a potential tumor suppressor, suggesting a crucial role in regulating tumorigenesis. Its designation as a tumor suppressor implies a capacity to counteract the uncontrolled cellular growth characteristic of cancer cells. By inhibiting or modulating key pathways involved in tumor development, ITIH5 may contribute to the maintenance of normal cellular function and prevention of malignant transformation. The characterization of ITIH5 as a putative tumor suppressor underscores its significance in the intricate network of cellular regulatory mechanisms, warranting further investigation into its specific mechanisms of action and potential therapeutic implications in cancer management.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

Q86UX2 (35V-161E)

Gene ID

80760

Molecular Construction
N-term
ITIH5 (35V-161E)
Accession # Q86UX2
hFc
C-term
Synonyms
ITI heavy chain H5; ITI-HC5; Inter-alpha-inhibitor heavy chain 5; ITIH5
AA Sequence

VPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEE

Molecular Weight

Approximately 50 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

ITIH5 Protein, Human (HEK293, His-hFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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ITIH5 Protein, Human (HEK293, His-hFc)
Cat. No.:
HY-P701322
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