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KCNK13 Protein, Human (Cell-Free, His)

Cat. No.: HY-P702347
Handling Instructions

KCNK13 Protein, a potassium channel, uniquely features weak inward rectification in symmetrical K(+) solution. As a homodimer, it regulates potassium ion flow across cellular membranes, impacting cellular excitability and membrane potential. This property highlights KCNK13's role in shaping electrochemical gradients, influencing processes reliant on potassium ion dynamics. KCNK13 Protein, Human (Cell-Free, His) is the recombinant human-derived KCNK13 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNK13 Protein, Human (Cell-Free, His) is 408 a.a., with molecular weight of 51.4 kDa.

For research use only. We do not sell to patients.

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Description

KCNK13 Protein, a potassium channel, uniquely features weak inward rectification in symmetrical K(+) solution. As a homodimer, it regulates potassium ion flow across cellular membranes, impacting cellular excitability and membrane potential. This property highlights KCNK13's role in shaping electrochemical gradients, influencing processes reliant on potassium ion dynamics. KCNK13 Protein, Human (Cell-Free, His) is the recombinant human-derived KCNK13 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNK13 Protein, Human (Cell-Free, His) is 408 a.a., with molecular weight of 51.4 kDa.

Background

KCNK13 Protein, a potassium channel, exhibits a distinct functional profile characterized by weak inward rectification in symmetrical K(+) solution. As a homodimer, KCNK13 contributes to the regulation of potassium ion flow across cellular membranes, playing a role in the modulation of cellular excitability and membrane potential. This unique property of weak inward rectification underscores KCNK13's involvement in shaping the electrochemical gradients across cell membranes, ultimately influencing cellular processes that rely on potassium ion dynamics.

Species

Human

Source

E. coli Cell-free

Tag

N-10*His

Accession

Q9HB14 (M1-R408)

Gene ID

56659

Molecular Construction
N-term
10*His
KCNK13 (M1-R408)
Accession # Q9HB14
C-term
Synonyms
Potassium channel subfamily K member 13; Tandem pore domain halothane-inhibited potassium channel 1; THIK-1
AA Sequence

MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSCHQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVRNRCNISIETDGVAESDTDGRRLSGEMISMKDLLAANKASLAILQKQLSEMANGCPHQTSTLARDNEFSGGVGAFAIMNNRLAETSGDR

Molecular Weight

51.4 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

KCNK13 Protein, Human (Cell-Free, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
KCNK13 Protein, Human (Cell-Free, His)
Cat. No.:
HY-P702347
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