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  4. KCNN2 Protein, Rat (Cell-Free, His)

KCNN2 Protein, Rat (Cell-Free, His)

Cat. No.: HY-P702349
Handling Instructions

KCNN2 is a voltage-dependent potassium channel that is activated by intracellular calcium, leading to membrane hyperpolarization. This channel is thought to regulate neuronal excitability by promoting a slow component of postsynaptic hyperpolarization. KCNN2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived KCNN2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNN2 Protein, Rat (Cell-Free, His) is 580 a.a., with molecular weight of 69.9 kDa.

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Description

KCNN2 is a voltage-dependent potassium channel that is activated by intracellular calcium, leading to membrane hyperpolarization. This channel is thought to regulate neuronal excitability by promoting a slow component of postsynaptic hyperpolarization. KCNN2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived KCNN2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNN2 Protein, Rat (Cell-Free, His) is 580 a.a., with molecular weight of 69.9 kDa.
Background

The KCNN2 (Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2) protein functions as a voltage-independent potassium channel, responding to intracellular calcium levels according to references. Upon activation by calcium, it induces membrane hyperpolarization, playing a role in regulating neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The inhibitory effects of bee venom neurotoxin apamin, as well as UCL 1684 and tetraethylammonium (TEA), highlight potential pharmacological modulation of KCNN2 activity.
Species

Rat
Source

E. coli Cell-free
Tag

N-10*His
Accession

P70604 (M1-S580)
Gene ID

54262
Molecular Construction
N-term
10*His
KCNN2 (M1-S580)
Accession # P70604
C-term
Synonyms
Small conductance calcium-activated potassium channel protein 2; KCa2.2
AA Sequence

MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

Molecular Weight

69.9 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

KCNN2 Protein, Rat (Cell-Free, His) Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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