Myeloperoxidase/MPO Protein, Human (HEK293, C-His)

Myeloperoxidase (MPO) Protein is a crucial component of polymorphonuclear leukocytes, vital for microbicidal activity against diverse organisms. Upon leukocyte stimulation, MPO catalyzes the generation of hypohalous acids, predominantly hypochlorous acid, enhancing microbicidal activity. This enzymatic defense mechanism contributes to the host's ability to combat pathogens. Additionally, MPO is involved in proteolytic cleavage of alpha-1-microglobulin, generating t-alpha-1-microglobulin, which inhibits low-density lipoprotein oxidation, providing vascular protection. MPO's multifaceted functions highlight its critical role in immune defense and vascular health. Myeloperoxidase/MPO Protein, Human (HEK293, C-His) is the recombinant human-derived Myeloperoxidase/MPO protein, expressed by HEK293, with C-6*His labeled tag. The total length of Myeloperoxidase/MPO Protein, Human (HEK293, C-His) is 697 a.a., with molecular weight of approximately 95 kDa.

Myeloperoxidase (MPO) Protein constitutes a crucial component of the host defense system within polymorphonuclear leukocytes, playing a pivotal role in microbicidal activity against a diverse spectrum of organisms. Upon stimulation of polymorphonuclear leukocytes, MPO catalyzes the generation of hypohalous acids, predominantly hypochlorous acid under physiological conditions, along with other toxic intermediates that significantly enhance microbicidal activity in these cells. This enzymatic activity serves as a potent defense mechanism, contributing to the host's ability to combat various pathogens. Furthermore, MPO is implicated in the proteolytic cleavage of alpha-1-microglobulin, generating t-alpha-1-microglobulin, a molecule known for its capacity to inhibit the oxidation of low-density lipoprotein particles and thereby mitigate vascular damage. These multifaceted functions underscore the critical role of MPO in immune defense and vascular protection.

Human

HEK293

C-6*His

P05164 (A49-S745)

4353  [NCBI]

AAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS

approximately 95 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.