SLC26A4 Protein, Human (Cell-Free, His)

SLC26A4 Protein, a sodium-independent transporter, crucially facilitates chloride and iodide transport, mediating electroneutral chloride-bicarbonate, chloride-iodide, and chloride-formate exchanges, each with a 1:1 stoichiometry. It's also implicated in electroneutral iodide-bicarbonate exchange, highlighting its versatility in transporting essential anions. The precise stoichiometry and electrogenic nature underscore its significance in maintaining cellular ion balance and regulating chloride and iodide ions. SLC26A4 emerges as a key player in cellular physiology, contributing to critical processes where chloride and iodide homeostasis is essential. SLC26A4 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC26A4 protein, expressed by E. coli Cell-free , with N-6*His labeled tag and H723R mutation. The total length of SLC26A4 Protein, Human (Cell-Free, His) is 780 a.a., with molecular weight of 86.7 kDa.

SLC26A4, a sodium-independent transporter, operates in the facilitation of chloride and iodide transport. This transporter, documented in various studies, plays a crucial role in mediating electroneutral chloride-bicarbonate, chloride-iodide, and chloride-formate exchange, each occurring with a 1:1 stoichiometry. Additionally, SLC26A4 is implicated in electroneutral iodide-bicarbonate exchange, demonstrating its versatility in transporting essential anions. The precise stoichiometry and electrogenic nature of these exchanges underscore the transporter's significance in maintaining cellular ion balance and regulating the movement of chloride and iodide ions. These functions position SLC26A4 as a key player in cellular physiology, contributing to diverse processes where chloride and iodide homeostasis is critical.

Human

E. coli Cell-free

N-6*His

O43511 (M1-S780, H723R)

5172

MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVRDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS

86.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.