SLC40A1 Protein, Human (Sf9, His, MBP, FLAG)

SLC40A1 plays a pivotal role in systemic iron homeostasis by transporting Fe(2+) from cells to the bloodstream. Essential for maintaining iron balance, it enables dietary iron uptake, recycling by macrophages and erythrocytes, and controlled release from hepatocytes. In iron surplus, elevated HAMP/hepcidin levels prompt SLC40A1 degradation, limiting iron efflux into the plasma. SLC40A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC40A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC40A1 Protein, Human (Sf9, His, MBP, FLAG) is 570 a.a., .

SLC40A1 emerges as a crucial player in systemic iron homeostasis by orchestrating the transportation of Fe(2+) from the intracellular milieu to the extracellular space. With a central role in maintaining the delicate balance of iron levels, SLC40A1 facilitates the transfer of iron from various cell types, including intestinal, splenic, hepatic cells, macrophages, and erythrocytes, into the bloodstream, ensuring a steady supply of iron to diverse tissues (By similarity). This multifaceted protein governs essential processes such as dietary iron uptake, recycling of iron by macrophages and erythrocytes, and the controlled release of iron stores in hepatocytes (By similarity). Notably, in conditions of iron surplus in the serum, elevated levels of circulating HAMP/hepcidin prompt the degradation of SLC40A1, thereby restricting the efflux of iron into the plasma.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q9NP59 (T2-V571)

30061

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.