TMC1 Protein, Mouse (Cell-Free, His)

The TMC1 protein is a possible ion channel critical for cochlear hair cell function. Its important interaction with TOMT facilitates transport into stereocilia. TMC1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived TMC1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TMC1 Protein, Mouse (Cell-Free, His) is 757 a.a., with molecular weight of 90.1 kDa.

The TMC1 protein stands out as a probable ion channel essential for the normal function of cochlear hair cells. Its interaction with TOMT is crucial, and the collaborative effort of TMC1 and TMC2 with TOMT facilitates their transportation into the stereocilia of hair cells. Furthermore, TMC1 engages with both isoforms CD1 and CD3 of PCDH15 via its N-terminus, emphasizing its involvement in intricate cellular interactions within the cochlea. Additionally, TMC1 interacts with CIB2 and CIB3, underlining its role in diverse protein-protein associations that contribute to the overall function of cochlear hair cells. The multifaceted interactions of TMC1 highlight its significance in maintaining the proper functionality of these specialized cells in the auditory system.

Mouse

E. coli Cell-free

N-10*His

Q8R4P5 (M1-Q757)

13409

MLQIQVEEKEEDTEESSSEEEEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLRRGAEEEEEIDEEELERLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKKMAAARAAAAAGGQ

90.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.