TMEM65 Protein, Human (Cell-Free, His, SUMO)

The TMEM65 protein is critical for cardiac development, regulates GJA1 and affects gap junction communication. It contributes to the stability of GJA1 in cardiac intercalary disks, and there are indications that it is involved in mitochondrial function. TMEM65 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived TMEM65 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of TMEM65 Protein, Human (Cell-Free, His, SUMO) is 178 a.a., with molecular weight of 35.1 kDa.

TMEM65 Protein emerges as a potentially crucial player in cardiac development and function, with implications in the regulation of cardiac conduction and the function of the gap junction protein GJA1. By contributing to the stability and proper localization of GJA1 to the cardiac intercalated disk, TMEM65 may play a pivotal role in regulating gap junction communication. Additionally, there are indications that TMEM65 could be involved in the regulation of mitochondrial respiration and maintenance of mitochondrial DNA copy number. Existing as both a monomer and a homodimer, TMEM65 interacts with GJA1 and weakly with DSP, suggesting its multifaceted involvement in cellular processes critical for cardiac and mitochondrial function. Further investigations are essential to elucidate the intricate molecular pathways through which TMEM65 exerts its diverse functions.

Human

E. coli Cell-free

N-6*His;N-SUMO

Q6PI78 (M63-S240)

157378

MEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS

35.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.