TRPC5 Protein, Human (HEK293, His, MBP, FLAG)

The TRPC5 protein is hypothesized to be a receptor-activated, nonselective calcium-permeable cation channel, possibly activated by phosphatidylinositol second messengers via receptor tyrosine kinases or G-protein-coupled receptors. Although TRPC5 is thought to have calcium-selective properties, it may also respond to depletion of intracellular calcium stores. TRPC5 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPC5 protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag. The total length of TRPC5 Protein, Human (HEK293, His, MBP, FLAG) is 972 a.a., .

TRPC5 protein is postulated to function as a receptor-activated non-selective calcium-permeant cation channel, potentially operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Although it has been suggested to exhibit calcium-selective properties, TRPC5 may also be activated by the depletion of intracellular calcium stores. The protein is implicated in mediating calcium-dependent phosphatidylserine externalization and apoptosis in neurons through its association with PLSCR1. Notably, the calcium channel activity of TRPC5 is enhanced by MYLK, which promotes its subcellular localization at the plasma membrane. This intricate regulatory network underscores the diverse ways in which TRPC5 may contribute to cellular signaling processes, with implications for calcium homeostasis and apoptotic pathways in neurons.

Human

HEK293

N-MBP;C-Flag;N-8*His

Q9UL62 (A2-L973)

7224

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.