USP19 Protein, Human

USP19 protein regulates protein degradation and prevents the breakdown of RNF123 and CDKN1B, thereby affecting cell proliferation. USP19 Protein, Human is the recombinant human-derived USP19 protein, expressed by E. coli , with tag free. The total length of USP19 Protein, Human is 415 a.a., .

The USP19 protein functions as a pivotal deubiquitinating enzyme, intricately regulating the degradation of diverse proteins and influencing various cellular processes. Notably, it deubiquitinates and shields RNF123 from proteasomal degradation, leading to the stimulation of CDKN1B ubiquitin-dependent degradation and contributing to cell proliferation. USP19 is implicated in decreased protein synthesis in atrophying skeletal muscle and modulates the transcription of major myofibrillar proteins. Additionally, it plays a crucial role in the turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates and regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. In the context of cellular response to hypoxia, USP19 is required for mounting an appropriate response and rescues HIF1A from degradation in a non-catalytic manner. Moreover, it plays a significant role in 17 beta-estradiol (E2)-inhibited myogenesis, acting to repress myogenesis and decreasing the levels of ubiquitinated proteins during skeletal muscle formation. USP19 exhibits a notable preference for 'Lys-63'-linked ubiquitin chains, highlighting its selectivity in substrate recognition and modulation of cellular pathways.

Human

E. coli

Tag Free

O94966 (E904-R1318)

10869

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.