USP33 Protein, Human

The USP33 protein is a critical deubiquitinase that complexly regulates centrosome duplication, cell migration, and beta-2 adrenergic receptor (ADRB2) recycling. During S and G2/M phases, USP33 deubiquitinates CCP110, stabilizing it and promoting centriole duplication. USP33 Protein, Human is the recombinant human-derived USP33 protein, expressed by E. coli , with tag free. The total length of USP33 Protein, Human is 941 a.a., .

USP33 Protein, a pivotal deubiquitinating enzyme, is intricately involved in various cellular processes, exerting influence over centrosome duplication, cellular migration, and the recycling of the beta-2 adrenergic receptor (ADRB2). In the regulation of centrosome duplication, USP33 mediates the deubiquitination of CCP110 during S and G2/M phases, thereby stabilizing CCP110 and facilitating centriole duplication and elongation. Furthermore, its interaction with the intracellular domain of ROBO1 contributes to cell migration, modulating the Slit signaling pathway. USP33 also plays a central role in commissural axon guidance across the ventral midline of the neural tube in a Slit-dependent manner, potentially by deubiquitinating ROBO1. As a key regulator of G-protein coupled receptor (GPCR) signaling, USP33 mediates the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and ADRB2, orchestrating ADRB2 recycling and resensitization after prolonged agonist stimulation. Additionally, it participates in thyroid hormone regulation by deubiquitinating DIO2 and displays versatility by mediating deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, highlighting its central role in cellular homeostasis and signaling pathways.

Human

E. coli

Tag Free

Q8TEY7 (T2-L942)

23032

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.