USP53 Protein, Human (His, GST)

USP53 protein, a critical element in tight junctions, is essential for the survival of auditory hair cells and the maintenance of hearing function. Although lacking peptidase activity, USP53's importance is highlighted by its interaction with the TJP1:TJP2 heterodimer, suggesting nuanced involvement in the molecular architecture of tight junctions. This interaction emphasizes USP53's potential impact on cellular survival and auditory processes. USP53 Protein, Human (His, GST) is the recombinant human-derived USP53 protein, expressed by E. coli , with N-6*His, N-GST labeled tag. The total length of USP53 Protein, Human (His, GST) is 322 a.a., .

USP53 protein, a crucial component in tight junctions, plays a vital role in the survival of auditory hair cells and the maintenance of hearing function, potentially through the modulation of tight junction barrier properties and mechanical stability. Despite lacking peptidase activity, USP53's significance in auditory function is underscored by its interaction, mediated by the C-terminal region, with the heterodimer TJP1:TJP2. This interaction suggests a nuanced involvement in the intricate molecular architecture of tight junctions, emphasizing its potential impact on cellular survival and auditory processes.

Human

E. coli

N-6*His;N-GST

Q70EK8 (K30-P351)

54532

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.