YopB Protein, Yersinia enterocolitica (Cell-Free, His, SUMO)

YopB, a vital component of the type III secretion system (T3SS), injects bacterial effectors into host cells by forming a membrane pore with YopD. Crucial for virulence, YopB facilitates effector translocation, including YopE, in Yersinia infections. While not directly targeting effectors, YopB may influence the host's immune response. YopB Protein, Yersinia enterocolitica (Cell-Free, His, SUMO) is the recombinant YopB protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of YopB Protein, Yersinia enterocolitica (Cell-Free, His, SUMO) is 401 a.a., with molecular weight of 57.9 kDa.

YopB, a crucial component of the type III secretion system (T3SS) or injectisome, participates in injecting bacterial effector proteins into eukaryotic host cells. Alongside YopD, YopB is integrated into the host membrane, forming a pore that facilitates the translocation of effector proteins into the cytosol of target cells. This process is fundamental for the virulence of the bacterium, as YopB is an essential virulence determinant. Its role extends to being required for the translocation of specific effectors like YopE and is indispensable for the establishment of Yersinia infections in a mouse model system. Interestingly, YopB does not play a direct role in targeting effector Yops but might influence the host's immune response at a distance from the infection site.

Others

E. coli Cell-free

N-6*His;N-SUMO

P37131 (M1-V401)

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MSALITHDRSTPVTGSLVPYIETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQEITKLLESVTRGTAGSQLISNYVSVLTNFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKSGMASKIFGWLIAIASVVIGAIMVASGVGAVAGAMMIASGVIGMANMAVKQAAEDGLISQEAMQVLGPILTAIEVALTVVSTVMTFGGSALKCLADIGAKLGANTASLAAKGAEFSAKVAQISTGISNTVGSAVTKLGGSFGSLTMSHVIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHRQVMELIFQMINAKGDMLHNLAGRPHTV

57.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.