2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. MDM2-p53-IN-15

MDM2-p53-IN-15 is a MDM2-p53 inhibitor with an IC50 value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer.

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MDM2-p53-IN-15 Chemical Structure

MDM2-p53-IN-15 Chemical Structure

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MDM2-p53-IN-15 Related Antibodies

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Description

MDM2-p53-IN-15 is a MDM2-p53 inhibitor with an IC50 value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer[1].

IC50 & Target

IC50: 26.1 nM (MDM2-p53)[1]
In Vitro

MDM2-p53-IN-15 (1–100 μM; 48 h) inhibits HCT116 cells proliferation[1].
MDM2-p53-IN-15 (10-20 μM; 72-96 h) affects SJSA-1, LNCaP and MCF-7 proliferation[1].
MDM2-p53-IN-15 (10-15 μM; 96 h) affects cell death and apoptosis in SJSA1 cells[1].
MDM2-p53-IN-15 (0-1 μM; 1 h 30 min) dissociates MDM2-p53 complexes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2-p53-IN-15 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT116 cells
Concentration: 1-100 μM
Incubation Time: 48 hours
Result: Showed antiproliferative activity to HCT116 cells with an IC50 value of 18.8 μM.

Cell Proliferation Assay[1]

Cell Line: SJSA-1, LNCaP and MCF-7 cell lines
Concentration: 10-20 μM
Incubation Time: 72 and 96 hours
Result: Inhibited SJSA-1, LNCaP and MCF-7 cells proliferation with IC50 values of 10.7, 11.4 and 9.7 μM, respectively.

Apoptosis Analysis[1]

Cell Line: SJSA-1 cells
Concentration: 10-15 μM
Incubation Time: 96 hours
Result: Approximately 1.3-fold increased LDH releases at a concentration of 15 μM approximately 1.3-fold increased and induced SJSA-1 cells death with loss of volume. Induced accumulation of cells in G0/G1 phase while decreased the percentage of cells in both S and G2/M phases, thus affects cell cycle.

Cell Viability Assay[1]

Cell Line: U87MG and SHSY-5Y cells
Concentration: 0-1 μM
Incubation Time: 1 h 30 min
Result: Selectively inhibited MDM2-p53 PPIs with an IC50 value of 26.1 nM, while inhibited MDM4-p53 PPIs with a lower potency with an IC50 value of 219 nM.
Molecular Weight

685.57

Formula

C38H26Cl2N6O3
SMILES

O=C(C([C@@H]1C2=CC=CC(O)=C2)=NN(C3=CC=C(Cl)C=C3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)NC6=CC=CC(N7N=C(C8=CC=CC=C8)C=C7)=C6.[Relative stereochemistry]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MDM2-p53-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2-p53-IN-15MDM-2/p53ApoptosisHCT116PPISJSA-1LNCaPMCF-7anti-proliferationapoptosiscell cycleInhibitorinhibitorinhibit

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