S-MTC dihydrochloride
Based on 1 Customer Validation
S-MTC (S-Methyl-L-thiocitrulline) dihydrochloride is a selective type I nitric oxide synthase (NOS) inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 209589-59-3
- Formula: C7H17Cl2N3O2S
- Molecular Weight:278.20
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
NOS[1]
S-MTC dihydrochloride (10 or 100 μM) reduces cellular NO release in the absence of Aβ1-42. At 100 μM, S-MTC dihydrochloride decreases cell viability. S-MTC dihydrochloride (100 μM) significantly lowers nitrite production (11.2±1.1 μM) when compared to control (no NOS inhibitor exposure; 19.6±1.2 μM). Nitrite productions after Aβ1-42 and L-NOARG (100 μM) or Aβ1-42 and S-MTC dihydrochloride (100 μM) treatments are significantly lower than Aβ1-42 alone (33.5±2.0 and 34.5±1.6 μM, respectively). S-MTC dihydrochloride (100 μM) is able to significantly reduce nitrite production (25.2±1.1 μM) as compared to Aβ1-42 treatment alone (38.3±2.7 μM), when administered after Aβ1-42 at the 1 h time point. S-MTC dihydrochloride (100 μM) concentration decreases both MTT (87±1% of control) and NR (80±1% of control, respectively) levels. The co-administration of S-MTC dihydrochloride (100 μM) and Aβ1-42 significantly reverses the effects of Aβ1-42 alone (72±2% vs 61±2% of control)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 209589-59-3
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Appearance Solid
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Molecular Weight 278.20
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Formula C7H17Cl2N3O2S
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Color White to off-white
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SMILES
N[C@@H](CCCNC(SC)=N)C(O)=O.[H]Cl.[H]Cl
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Synonyms
S-Methyl-L-thiocitrulline dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (359.45 mM)
DMSO : 20 mg/mL (71.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Law A, et al. Neuroprotective and neurorescuing effects of isoform-specific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity. Br J Pharmacol. 2001 Aug;133(7):1114-24. [Content Brief]
[2]. Zelinski LM, et al. A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygenin mice. J Pain. 2009 Feb;10(2):167-72. [Content Brief]
[3]. Wakefield ID, et al. Comparative regional haemodynamic effects of the nitric oxide synthase inhibitors, S-methyl-L-thiocitrulline and L-NAME, in conscious rats. Br J Pharmacol. 2003 Jul;139(6):1235-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.5945 mL | 17.9727 mL | 35.9454 mL | 89.8634 mL |
| 5 mM | 0.7189 mL | 3.5945 mL | 7.1891 mL | 17.9727 mL | |
| 10 mM | 0.3595 mL | 1.7973 mL | 3.5945 mL | 8.9863 mL | |
| 15 mM | 0.2396 mL | 1.1982 mL | 2.3964 mL | 5.9909 mL | |
| 20 mM | 0.1797 mL | 0.8986 mL | 1.7973 mL | 4.4932 mL | |
| 25 mM | 0.1438 mL | 0.7189 mL | 1.4378 mL | 3.5945 mL | |
| 30 mM | 0.1198 mL | 0.5991 mL | 1.1982 mL | 2.9954 mL | |
| 40 mM | 0.0899 mL | 0.4493 mL | 0.8986 mL | 2.2466 mL | |
| 50 mM | 0.0719 mL | 0.3595 mL | 0.7189 mL | 1.7973 mL | |
| 60 mM | 0.0599 mL | 0.2995 mL | 0.5991 mL | 1.4977 mL | |
| H2O | 80 mM | 0.0449 mL | 0.2247 mL | 0.4493 mL | 1.1233 mL |
| 100 mM | 0.0359 mL | 0.1797 mL | 0.3595 mL | 0.8986 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
S-MTC dihydrochloride Related Classifications
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