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Targets Recommended: NEDD8-activating Enzyme

Results for "73819-26-8" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-110137A
    Furamidine

    DB75; NSC 305831

    Parasite Histone Methyltransferase Cancer Infection Inflammation/Immunology
    Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively).