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Results for "

DGKα

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156577
    DGKα-IN-7

    		DGK Cancer
    DGKα-IN-7 is a DGKα inhibitor with the IC50 of 6.225 nM, extracted from patent WO2022271684 (compound 100). DGKα-IN-7 has the potential for cancer study.
    <em>DGKα</em>-IN-7
  • HY-156569
    DGKα-IN-2

    		DGK Inflammation/Immunology Cancer
    DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
    <em>DGKα</em>-IN-2
  • HY-156570
    DGKα-IN-3

    		DGK Inflammation/Immunology Cancer
    DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
    <em>DGKα</em>-IN-3
  • HY-156576
    DGKα-IN-6

    		DGK Cancer
    DGKα-IN-6 is a DGKα inhibitor with the IC50 of 1.377 nM, extracted from patent WO2022271650 (compound 143). DGKα-IN-6 has the potential for cancer study.
    <em>DGKα</em>-IN-6
  • HY-156575S
    DGKα-IN-5

    		Isotope-Labeled Compounds Others
    DGKα-IN-5 is a deuterium labeled compound.
    <em>DGKα</em>-IN-5
  • HY-156578
    DGKα-IN-8

    		DGK HIV Infection Cancer
    DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC50=22.491 nM; EC50=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection .
    <em>DGKα</em>-IN-8
  • HY-156571
    DGKα-IN-4

    		DGK Cancer
    DGKα-IN-4 (example 432) is a DGKα inhibitor with the IC50 of 0.1 nM, extracted from patent WO2021105117. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-3 has the potential for cancer and immunology study.
    <em>DGKα</em>-IN-4
  • HY-156573
    DGKα&ζ-IN-1

    		DGK Cancer
    DGKα&ζ-IN-1 (Compound II) is a DGK target inhibitor. DGKα&ζ-IN-1 can enhance the function of T cells, and has a synergistic effect with PD-1, which has therapeutic effects IN both immune and tumor .
    <em>DGKα</em>&ζ-IN-1
  • HY-149665
    BMS-684

    		DGK Cancer
    BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes .
    BMS-684
  • HY-156567
    AMB639752

    		DGK Metabolic Disease
    AMB639752 is a potent DGKα inhibitor. AMB639752 restores restimulation induced cell death (RICD) in SAP deficient lymphocytes by inhibiting DGKα in intact cells. AMB639752 can be used for X-linked lymphoproliferative disease 1(XLP-1) research .
    AMB639752

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