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O6-Benzylguanine

" in MedChemExpress (MCE) Product Catalog:

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Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W002585
    O6-Benzylguanine
    1 Publications Verification

    		 DNA/RNA Synthesis Apoptosis Cancer
    O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .
    <em>O6</em>-<em>Benzylguanine</em>

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