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Cat. No. Product Name Target Research Areas
  • HY-126255

    NAMPT Metabolic Disease
    SBI-797812 is a potent nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD +. SBI-797812 increases intracellular NMN and NAD + in cells, and elevates liver NAD + in mice.