2. GPCR/G Protein
  3. GLP Receptor
  4. Tirzepatide TFA

Tirzepatide TFA (LY3298176 hydrochloride) is a glucose-dependent insulin nutritive polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist. Tirzepatide TFA has neuroprotective effects and can be used in the study of type 2 diabetes, diabetes-related neuropathy and obesity.

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Tirzepatide TFA Chemical Structure

Tirzepatide TFA Chemical Structure

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Tirzepatide TFA Related Antibodies

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Description

Tirzepatide TFA (LY3298176 hydrochloride) is a glucose-dependent insulin nutritive polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist. Tirzepatide TFA has neuroprotective effects and can be used in the study of type 2 diabetes, diabetes-related neuropathy and obesity[1][2][3].

IC50 & Target

Glucose-dependent insulinotropic polypeptide (GIP), GLP-1 receptor[1]
In Vitro

Tirzepatide TFA (0-0.4 μM, 7 days) is used to improve the neurodegeneration of SHSY5Y human neuroblastoma cells induced by high glucose and to overcome neuronal insulin resistance[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tirzepatide TFA Related Antibodies

Western Blot Analysis[1]

Cell Line: SHSY5Y
Concentration: 0-0.4 μM
Incubation Time: 7 days
Result: Upregulated the mRNA expression and protein levels of both CREB and BDNF.
Increased the Bcl-2 and decreased BAX protein levels.
Increased the pAkt, MAP2, GAP43, and AGBL4 protein levels.
Increased GLUT4 and SORBS1 protein levels.
In Vivo

Tirzepatide TFA (10 nM/kg, subcutaneous injection) can inhibit colon cancer tumor growth in dietary-obese mice[2].
Tirzepatide TFA (1.35 mg/kg, intraperitoneal injection, once per week) improves spatial learning and memory impairment by modulating abnormal insulin resistance and inflammatory response in diabetic rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) mice [2]
Dosage: 10 nM/kg
Administration: s.c.
Result: Reduced body weight and food consumption.
Reduced glucose, insulin, leptin, and c-peptide levels.
Animal Model: MC38 colon cancer mice model[2]
Dosage: 10 nM/kg
Administration: s.c.
Result: Reduced tumor volumes.
Clinical Trial
Molecular Weight

4813.45 (free base)

Formula

C225H348N48O68.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{C20 diacid-gamma-Glu-(AEEA)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Sequence Shortening

Y-{Aib}-EGTFTSDYSI-{Aib}-LDKIAQ-{C20 diacid-gamma-Glu-(AEEA)2-Lys}-AFVQWLIAGGPSSGAPPPS-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Tirzepatide TFA Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TirzepatideLY3298176LY 3298176LY-3298176GLP ReceptorType 2 diabetesneuropathyAlzheimer's diseaseobesityInhibitorinhibitorinhibit

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