In This Webinar, You Will Learn:
• The challenge of clinical development of PI3K inhibitors
• The disconnection between the basic science and the impact in the clinic
• The update on alternative ways to modulate the PI3K pathway
About PI3K:
The intracellular PI 3-kinase (PI3K) signal transduction pathway regulates a broad range of cell biological activities, including cell proliferation and migration. PI3K signaling is frequently genetically activated in cancer and is involved in overgrowth syndromes and immune dysregulation.
About Dr. Vanhaesebroeck:
Dr. Vanhaesebroeck studies PI3K enzymes which control signal transduction in cells. PI3K overactivation occurs in cancer, some immune contexts and in overgrowth syndromes. Dr. Vanhaesebroeck aim to understand the mechanism of PI3K action in cells and organisms. Over the years, his studies have contributed to PI3K drug development, clinical trials and drug approval.
Dr. Vanhaesebroeck entered the PI3K field very early, at a time of isolation of the genes for the different PI3K family members and when signal transduction research was at its infancy. After isolating multiple PI3K genes, Dr. Vanhaesebroeck set out to characterize the roles of the different PI3K family members, identifying some as drug targets. This led to huge pharma efforts to develop PI3K inhibitors.
A highlight of Dr. Vanhaesebroeck’s work is the discovery of PI3Kdelta, a PI3K family member reported in 1997. Dr. Vanhaesebroeck’s laboratory performed a large body of the preclinical studies on this PI3K and helped to progress PI3Kdelta into drug development and clinical application. PI3Kdelta inhibitors are now approved for clinical use in B-cell lymphoma and Activated PI3Kdelta Syndrome (APDS).
Selected Publications:
[1] Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development. J Pathol. 2022 Dec;258(4):382-394.
[2] PI3K inhibitors are finally coming of age. Nat Rev Drug Discov. 2021 Oct;20(10):741-769.
[3] Cracking the context-specific PI3K signaling code. Sci Signal. 2020 Jan 7;13(613):eaay2940.
[4] PI3K isoforms in cell signalling and vesicle trafficking. Nat Rev Mol Cell Biol. 2019 Sep;20(9):515-534.
[5] Molecules in medicine mini-review: isoforms of PI3K in biology and disease. J Mol Med, 2016.
[6] PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol, 2012. 13(3): p. 195-203.
Learn More
https://www.ucl.ac.uk/cancer/research/department-oncology/cell-signalling-research-group
