α-Glucosidase-IN-57
α-Glucosidase-IN-57 (Compound 10c) is a competitive and orally active α-glucosidase inhibitor with an IC50 value of 0.180 μM and a Ki of 0.15 μM. α-Glucosidase-IN-57 can reduce fasting and overall blood glucose levels in mice, and can be used for anti-diabetes research.
For research use only. We do not sell to patients.
- CAS No.: 3034302-49-0
- Formula: C32H23FN4OS
- Molecular Weight:530.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
α-Glucosidase-in-57 (Compound 10c) (0, 0.045, 0.09, 0.18 μM) competes with the substrate p-NPG (HY-W039892) (1-16 μM) for the same active site of the α-Glucosidase enzyme. α-Glucosidase-IN-57 acts as a potent competitive inhibitor of alpha-glucosidase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
α-Glucosidase-IN-57 (10, 25, 50 mg/kg; Oral gavage (p.o.); once daily for 28 days) has hypoglycemic activity in a Wistar albino rat model of diabetes, including reduces fasting blood glucose levels, improves glucose tolerance, and possibly improves islet structure of pancreatic tissue[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar albino rats with diabetes[1]
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Dosage:α-Glucosidase-IN-57: 10, 25, 50 mg/kg; Acarbose: 50 mg/kg
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Administration:Oral gavage (p.o.); once daily for 28 days
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Result:In the first 7 days, fasting blood glucose levels were not significantly different from diabetic controls.
On day 14, significantly reduced blood glucose levels at oral doses of 25 and 50 mg/kg, while Acarbose (at oral doses of 50 mg/kg) achieved the same effect.
On day 21, had the best hypoglycemic effect with acarbose at oral doses of 25 and 50 mg/kg, which was significantly better than the diabetic control group.
On day 28, blood glucose levels were significantly lower than those in the diabetic control group.
Chemical Information
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CAS No. 3034302-49-0
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Molecular Weight 530.61
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Formula C32H23FN4OS
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SMILES
O=C(CSC1=NC2=CC=CC=C2C=C1C3=NC(C4=CC=CC=C4)=C(N3)C5=CC=CC=C5)NC6=CC=C(F)C=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Glucosidase-IN-57 Related Classifications
HY-163433 Related Classifications
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