2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. α-Glucosidase-IN-57

α-Glucosidase-IN-57 (Compound 10c) is a competitive and orally active α-glucosidase inhibitor with an IC50 value of 0.180 μM and a Ki of 0.15 μM. α-Glucosidase-IN-57 can reduce fasting and overall blood glucose levels in mice, and can be used for anti-diabetes research.

For research use only. We do not sell to patients.

α-Glucosidase-IN-57 Chemical Structure

α-Glucosidase-IN-57 Chemical Structure

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α-Glucosidase-IN-57 Related Antibodies

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Description

α-Glucosidase-IN-57 (Compound 10c) is a competitive and orally active α-glucosidase inhibitor with an IC50 value of 0.180 μM and a Ki of 0.15 μM. α-Glucosidase-IN-57 can reduce fasting and overall blood glucose levels in mice, and can be used for anti-diabetes research[1].

In Vitro

α-Glucosidase-in-57 (Compound 10c) (0, 0.045, 0.09, 0.18 μM) competes with the substrate p-NPG (HY-W039892) (1-16 μM) for the same active site of the α-Glucosidase enzyme. α-Glucosidase-IN-57 acts as a potent competitive inhibitor of alpha-glucosidase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-57 Related Antibodies
In Vivo

α-Glucosidase-IN-57 (Compound 10c) (250, 500, 1000 mg/kg; Oral gavage (p.o.); 72h) is well tolerated and safe in Wistar albino rat models[1].
α-Glucosidase-IN-57 (10, 25, 50 mg/kg; Oral gavage (p.o.); once daily for 28 days) has hypoglycemic activity in a Wistar albino rat model of diabetes, including reduces fasting blood glucose levels, improves glucose tolerance, and possibly improves islet structure of pancreatic tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats with diabetes[1]
Dosage: α-Glucosidase-IN-57: 10, 25, 50 mg/kg; Acarbose: 50 mg/kg
Administration: Oral gavage (p.o.); once daily for 28 days
Result: In the first 7 days, fasting blood glucose levels were not significantly different from diabetic controls.
On day 14, significantly reduced blood glucose levels at oral doses of 25 and 50 mg/kg, while Acarbose (at oral doses of 50 mg/kg) achieved the same effect.
On day 21, had the best hypoglycemic effect with acarbose at oral doses of 25 and 50 mg/kg, which was significantly better than the diabetic control group.
On day 28, blood glucose levels were significantly lower than those in the diabetic control group.
Molecular Weight

530.61

Formula

C32H23FN4OS
SMILES

O=C(CSC1=NC2=CC=CC=C2C=C1C3=NC(C4=CC=CC=C4)=C(N3)C5=CC=CC=C5)NC6=CC=C(F)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Glucosidase-IN-57 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-57GlucosidaseAnti-diabetic2-(quinoline-2-ylthio)acetamidType 2 diabetes mellitusInhibitorinhibitorinhibit

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