1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor

1,4-Chrysenequinone (Synonyms: Chrysene-1,4-dione)

Cat. No.: HY-111441 Purity: >93.0%
Handling Instructions

1,4-Chrysenequinone (Chrysene-1,4-dione), a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

For research use only. We do not sell to patients.

1,4-Chrysenequinone Chemical Structure

1,4-Chrysenequinone Chemical Structure

CAS No. : 100900-16-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 100 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

1,4-Chrysenequinone (Chrysene-1,4-dione), a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

IC50 & Target

AhR[1]

In Vitro

1,4-Chrysenequinone shows significant AhR ligand activity, with ECTCDD25s (concentration equivalent with 25% of TCDD max) of 9.7 nM and 1.9 μM in yeast and mouse hepatoma cell systems, respectively[1].

References
Cell Assay
[1]

Mouse hepatoma (H1L1.1c2) cells (1.5 × 105 cells/well) are cultured in 96-well culture plates, and samples (1,4-Chrysenequinone) dissolved in dimethyl sulfoxide are added to the medium to achieve a final solvent concentration of 1%. After the plates are incubated at 37°C in 5% CO2 for 24 h, the cell viability is confirmed under a microscope. Subsequently, the medium is removed, and the cells are lysed. Adding luciferin as the substrate, the luciferase activity is determined under a luminometer and reported as relative light units. The concentrations producing luciferase activity equal to 25% of the maximal response to TCDD are calculated and also referred to as the ECTCDD25. The ratios of the ECTCDD25 of B[a]P to the ECTCDD25 of each of the compounds are calculated and referred to as IEFs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

258.27

Formula

C₁₈H₁₀O₂

CAS No.

100900-16-1

SMILES

O=C(C1=C2C=CC3=C1C=CC4=CC=CC=C43)C=CC2=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
1,4-Chrysenequinone
Cat. No.:
HY-111441
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1,4-Chrysenequinone

Cat. No.: HY-111441