2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. ACP-105

ACP-105 

Cat. No.: HY-112256 Purity: 99.33%
COA Handling Instructions

ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.

For research use only. We do not sell to patients.

ACP-105 Chemical Structure

ACP-105 Chemical Structure

CAS No. : 899821-23-9

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Solution
10 mM * 1 mL in DMSO USD 141 In-stock
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10 mM * 1 mL
ready for reconstitution
 USD 141 In-stock
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10 mg USD 220 In-stock
25 mg USD 440 In-stock
50 mg USD 680 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.

IC50 & Target

pEC50: 9.0 (AR wild type), 9.3 (AR T877A mutant)[1].
In Vitro

ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 (compound 1) in human hepatocytes is measured and found to be 5.0 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

ACP-105 enhances freezing in both sham-irradiated and irradiated mice (effect of ACP-105: F=5.44; p=0.028). For MAP-2 immunoreactivity in the cortex of sham-irradiated mice, there is a brain area×ACP-105 interaction (F=6.655; p=0.0027). While ACP-105 reduces MAP-2 immunoreactivity in the sensorymotor cortex, there is a trend towards increased MAP-2 immunoreactivity in the enthorhinal cortex[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

290.79

Appearance

Solid

Formula

C16H19ClN2O
CAS No.
SMILES

N#CC1=CC=C(N2[[email protected]@H]3C[[email protected]](O)(C)C[[email protected]]2CC3)C(C)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 103 mg/mL (354.21 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4389 mL 17.1945 mL 34.3891 mL
5 mM 0.6878 mL 3.4389 mL 6.8778 mL
10 mM 0.3439 mL 1.7195 mL 3.4389 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
Animal Administration
[2]

Mice[2]
Two-month-old C56Bl/6J female mice are kept on a 12:12 hr light-dark schedule (lights on at 6 AM) with lab chow and water given ad libitum. Following i.p. anesthesia (ketamine, 80 mg/kg and xylazine, 20 mg/kg), mice are sham-irradiated (n=7 sham vehicle-treated mice and n=7 ACP-105-treated mice) or irradiated (n=8 vehicle-treated mice and n=7 ACP-105-treated mice) using a dose of 10 Gy in a Mark 1 Cesium Irradiator. Twenty-four hours following irradiation, the mice are implanted with Alzet minipumps filled with ACP-105 at 1 mg/kg/day or 1.09 mg/200 μL in 10% Tween in saline or vehicle. Behavioral testing starts two weeks after irradiation. Mice receives three trials per day for three subsequent days. Mice are tested for fear conditioning in week 2. During contextual fear conditioning, mice learn to associate the environmental context with a mild foot shock. Contextual conditioned fear is assessed during the first 3 minutes of the contextual test trial when freezing behavior is most robust. Cued conditioned fear is assessed during the presentation of the tone (the last 3 minutes of the trial)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

ACP-105899821-23-9ACP105ACP 105Androgen ReceptorInhibitorinhibitorinhibit

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