1. JAK/STAT Signaling
  2. Pim
  3. AZD1208 hydrochloride

AZD1208 hydrochloride 

Cat. No.: HY-15604A
Handling Instructions

AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor.

For research use only. We do not sell to patients.

AZD1208 hydrochloride Chemical Structure

AZD1208 hydrochloride Chemical Structure

CAS No. : 1621866-96-3

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Top Publications Citing Use of Products

    AZD1208 hydrochloride purchased from MCE. Usage Cited in: ENeuro. 2019 Aug 22;6(4):ENEURO.0003-19.2019.

    PIM and PRK kinases function similarly in vitro. PRK-1 autophosphorylation was analysed in the absence (-) or presence (+) of 10 μM DHPCC-9, AZD-1208 and SGI-1776. The phosphorylated protein was visualized by immunoblotting with the phospho-RXXS*/T* antibody, which has several potential target sites in PRK-1.
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    AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor[1].

    IC50 & Target


    In Vitro

    AZD1208 hydrochloride shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 hydrochloride (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cells at 1 μM. AZD1208 hydrochloride induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 hydrochloride and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight




    CAS No.

    Room temperature in continental US; may vary elsewhere.


    Please store the product under the recommended conditions in the Certificate of Analysis.

    Solvent & Solubility
    In Vitro: 

    DMSO : 83.3 mg/mL (200.27 mM; Need ultrasonic and warming)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4042 mL 12.0210 mL 24.0419 mL
    5 mM 0.4808 mL 2.4042 mL 4.8084 mL
    10 mM 0.2404 mL 1.2021 mL 2.4042 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Cell Assay

    MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound (including AZD1208 hydrochloride) or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37˚C and reading of fluorescence on a Tecan Infinite® 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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