2. JAK/STAT Signaling Autophagy Apoptosis
  3. Pim Autophagy Apoptosis
  4. AZD1208 hydrochloride

AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor.

For research use only. We do not sell to patients.

CAS No. : 1621866-96-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of AZD1208 hydrochloride:

Other Forms of AZD1208 hydrochloride:

AZD1208 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    AZD1208 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 6:e03487.  [Abstract]

    Protein level of p-STAT1/2 in HEK293T cells treated with PIM1 inhibitor AZD-1208 (0, 2, 4, 8 μM) for 24h followed by the stimulation with/without poly: IC for 16 h, or IFN for 1h.

    AZD1208 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 6:e03487.  [Abstract]

    PIM inhibitors AZD-1208 (0-12 μM) pre-treated with RD cells for 2h, followed by the OC43 infection for 72h at the MOI of 0.01. OC43 viral RNA were determined.

    AZD1208 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 6:e03487.  [Abstract]

    PIM inhibitors AZD-1208 (0-12 μM) pre-treated with RD cells for 2h, followed by the OC43 infection for 72h at the MOI of 0.01. OC43 viral N protein was determined.

    AZD1208 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 6:e03487.  [Abstract]

    Protein level of -TrCP1 in HEK293T cells treated with the indicated concentration of PIM1 inhibitor AZD-1208 (0-12 μM) for 48h.

    AZD1208 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 6:e03487.  [Abstract]

    Western blot for IFNAR1 expression in HEK293T or HepG2 cells treated with PIM1 inhibitors AZD-1208 (0, 2, 4, 8 μM) for 48 h.

    AZD1208 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Apr 23;10(1):1844.  [Abstract]

    Primary monocytes were differentiated into macrophages and infected with HIV-2 reporter virus carrying wild-type Vpx or its S13A mutants. A pan-PIM kinase inhibitor AZD1208 (0, 0.1, 0.5 μM) was added 4 h before infection. Fortyeight hours post-infection, cells were harvested and subjected to luciferase assay.

    AZD1208 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Apr 23;10(1):1844.  [Abstract]

    Primary monocytes were differentiated into macrophages and infected with HIV-2 reporter virus carrying wild-type Vpx or its S13A mutants. A pan-PIM kinase inhibitor AZD1208 (0, 0.1, 0.5 μM) was added 4 h before infection. Fortyeight hours post-infection, cells were harvested and immunoblotting to measure HIV-2 infectivity and SAMHD1 expression.

    View All Pim Isoform Specific Products:

    View All Isoforms
    PIM1 PIM2 PIM3

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor[1].

    IC50 & Target

    PIM2

     

    In Vitro

    AZD1208 hydrochloride shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 hydrochloride (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cells at 1 μM. AZD1208 hydrochloride induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 hydrochloride and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    AZD1208 hydrochloride Related Antibodies
    Molecular Weight

    415.94

    Formula

    C21H22ClN3O2S
    CAS No.
    SMILES

    O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    DMSO : 83.3 mg/mL (200.27 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4042 mL 12.0210 mL 24.0419 mL
    5 mM 0.4808 mL 2.4042 mL 4.8084 mL
    View the Complete Stock Solution Preparation Table

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References
    Cell Assay
    [1]

    MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound (including AZD1208 hydrochloride) or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37˚C and reading of fluorescence on a Tecan Infinite® 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.4042 mL 12.0210 mL 24.0419 mL 60.1048 mL
    5 mM 0.4808 mL 2.4042 mL 4.8084 mL 12.0210 mL
    10 mM 0.2404 mL 1.2021 mL 2.4042 mL 6.0105 mL
    15 mM 0.1603 mL 0.8014 mL 1.6028 mL 4.0070 mL
    20 mM 0.1202 mL 0.6010 mL 1.2021 mL 3.0052 mL
    25 mM 0.0962 mL 0.4808 mL 0.9617 mL 2.4042 mL
    30 mM 0.0801 mL 0.4007 mL 0.8014 mL 2.0035 mL
    40 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5026 mL
    50 mM 0.0481 mL 0.2404 mL 0.4808 mL 1.2021 mL
    60 mM 0.0401 mL 0.2003 mL 0.4007 mL 1.0017 mL
    80 mM 0.0301 mL 0.1503 mL 0.3005 mL 0.7513 mL
    100 mM 0.0240 mL 0.1202 mL 0.2404 mL 0.6010 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    AZD1208 hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AZD12081621866-96-3AZD 1208AZD-1208PimAutophagyApoptosisPim kinasesInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    AZD1208 hydrochloride
    Cat. No.:
    HY-15604A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.