Cicloprolol hydrochloride 

Cicloprolol is a partial β 1-adrenoceptor agonist .

Adrenoceptor^[1]

Cicloprolol is a partial β1-adrenoceptor agonist considered for the treatment of patients with coronary artery disease and impaired left ventricular function^[1]. The new β-adrenoceptor partial agonist Cicloprolol acts as a β-agonist at normal levels and as a β-antagonist at high levels of adrenergic discharge. Treatment with Cicloprolol should protect the heart against excessive stimulation, while providing a baseline level of sympathetic drive. Cicloprolol has a weak β1-agonistic effect at normal levels of adrenergic discharge and acts as an antagonist at high levels of discharge^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

359.89

C₁₈H₃₀ClNO₄

63686-79-3

OC(CNC(C)C)COC1=CC=C(OCCOCC2CC2)C=C1.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Weber S, et al. Pharmacodynamic without pharmacokinetic interaction between cicloprolol, a partial beta 1-adrenoceptor agonist, and digoxin in healthy subjects. Br J Clin Pharmacol. 1990 Sep;30(3):411-6  [Content Brief]

  [2]. Cocco G, et al. An evaluation of the safety of the beta-modulator cicloprolol in chronic heart failure. Clin Cardiol. 1992 Jan;15(1):38-42.  [Content Brief]