2. Autophagy
  3. Autophagy
  4. Dansylcadaverine

Dansylcadaverine  (Synonyms: Monodansyl cadaverine)

Cat. No.: HY-D1027 Purity: 98.80%
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Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands.

For research use only. We do not sell to patients.

CAS No. : 10121-91-2

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Based on 13 publication(s) in Google Scholar

Other Forms of Dansylcadaverine:

Dansylcadaverine Related Antibodies

Top Publications Citing Use of Products

    Dansylcadaverine purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2025 Dec 10:S0016-5085(25)05907-4.  [Abstract]

    Endocytosis inhibitor Dansylcadaverine (DC) (80 μM; i.v.; twice a week) inhibited the endocytosis of OG-collagen IV (green) by mesothelial cells.

    Dansylcadaverine purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2025 Dec 10:S0016-5085(25)05907-4.  [Abstract]

    Dansylcadaverine (DC) (80 μM; i.v.; twice a week) significantly inhibited the endocytosis effect of collagen by mesothelial cells mediated by CLUtide-3-LRP2 interaction.

    Dansylcadaverine purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2025 Dec 10:S0016-5085(25)05907-4.  [Abstract]

    SR and Masson staining in fibrotic livers from Clu-/- mice treated with Dansylcadaverine (DC) (80 μM; i.v.; twice a week) as indicated.

    Dansylcadaverine purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2025 Dec 10:S0016-5085(25)05907-4.  [Abstract]

    Col1A1 and quantification in fibrotic livers from Clu-/- mice treated with Dansylcadaverine (DC) (80 μM; i.v.; twice a week) as indicated.

    Dansylcadaverine purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70133.  [Abstract]

    Dansylcadaverine (Da) (180 µM; 24 h) was able to efficiently block vesicle incorporation into 4T1 cells by 50% at a concentration that was non-toxic for the cells.

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2].

    In Vitro

    The inhibitory activity of dansylcadaverine reflects its ability to serve as a substrate for transglutaminases and to block competitively the crosslinking of fibrin molecules[2].
    Dansylcadaverine, a cationic fluorescent probe binds to bacterial lipopolysaccharide and lipid A, and is displaced competitively by other compounds which possess affinity toward endotoxins[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Dansylcadaverine Related Antibodies
    Molecular Weight

    335.46

    Formula

    C17H25N3O2S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NCCCCCNS(=O)(C1=CC=CC2=C1C=CC=C2N(C)C)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (186.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9810 mL 14.9049 mL 29.8098 mL
    5 mM 0.5962 mL 2.9810 mL 5.9620 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 98.80%

    SDS (393 KB)

    COA (248 KB) HNMR (135 KB) RP-HPLC (249 KB) LCMS (103 KB)

    Handling Instructions (2659 KB)
    Dyeing Example
    References
    Kinase Assay
    [1]

    To determine the time course of transglutamination, thymosin β4 (120 μM) is incubated with Dansylcadaverine (5 mM) in 70 μL buffer consisting of 10 mM Tris-HCl, pH 7.4, 15 mM CaCl2, 3 mM DTT. The reaction is started by addition of 0.1 U transglutaminase. Immediately after addition of the enzyme (t=0) and at indicated times,10 μL are taken from the mixture, diluted in 490 μL 0.1% TFA to stop the reaction and analyzed by HPLC[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Cell Assay

    MCF7 cells (2.4×104) are seeded into 35 mm plates. After 24 h incubation, CuO NPs are added with an increasing concentration in the presence or absence of 3-Methyladenine (3-MA) for different time periods . The cells are then incubated with 50 mM Dansylcadaverine (MDC) at 37°C for 15 min and washed with 1×PBS three times with 5 min interval. Finally, the cells are observed under a fluorescence microscope[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9810 mL 14.9049 mL 29.8098 mL 74.5245 mL
    5 mM 0.5962 mL 2.9810 mL 5.9620 mL 14.9049 mL
    10 mM 0.2981 mL 1.4905 mL 2.9810 mL 7.4525 mL
    15 mM 0.1987 mL 0.9937 mL 1.9873 mL 4.9683 mL
    20 mM 0.1490 mL 0.7452 mL 1.4905 mL 3.7262 mL
    25 mM 0.1192 mL 0.5962 mL 1.1924 mL 2.9810 mL
    30 mM 0.0994 mL 0.4968 mL 0.9937 mL 2.4842 mL
    40 mM 0.0745 mL 0.3726 mL 0.7452 mL 1.8631 mL
    50 mM 0.0596 mL 0.2981 mL 0.5962 mL 1.4905 mL
    60 mM 0.0497 mL 0.2484 mL 0.4968 mL 1.2421 mL
    80 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.9316 mL
    100 mM 0.0298 mL 0.1490 mL 0.2981 mL 0.7452 mL
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    Dansylcadaverine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dansylcadaverine10121-91-2Monodansyl cadaverineAutophagyautofluorescentprobeautophagicvacuolessubstrateInhibitorinhibitorinhibit

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